Synthetic Peptide Analogues
FOX04-DRI
10mgC₁₀₆H₁₄₁N₂₁O₂₈S₂
Key Research Findings
- Baar et al. — characterisation of the FOXO4-binding D-retro-inverso peptide.
- Published cell-culture studies on p21 and p16 senescence-marker transcription.
- Animal-model in-vitro data on p53 nuclear-export pathway.
Overview
FOX04-DRI is a synthetic D-retro-inverso peptide designed to interfere with the FOXO4–p53 protein-protein interaction. Supplied as a lyophilised powder for in-vitro research use only.
Mechanism of Action
Reported in published in-vitro studies as a competitive binder of FOXO4 that releases nuclear-sequestered p53 in cell-culture senescence-model assays. Not intended for human or veterinary use.
Research Effects
FOXO4–p53 Interaction Assays
Moderate ResearchReported in cell-culture assays as a competitive disruptor of the FOXO4–p53 protein-protein interaction.
Senescence-Marker Studies
Moderate ResearchPublished in-vitro studies report changes in p21 and p16 transcription in cultured cells.
Apoptosis Cell-Culture Assays
Preliminary ResearchEarly-stage in-vitro apoptosis-marker studies in senescence cell models.
Laboratory Research Only — All information on this page is provided for scientific research purposes only. This is a certified reference material sample sold and distributed for laboratory research only.
Quick Facts
Research Status Key
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Cellular & Metabolic Compounds
NAD+
NAD+ is nicotinamide adenine dinucleotide, a redox coenzyme present in every living cell and one of the most studied molecules in biochemistry. It is not a peptide, and we group it under cellular and metabolic compounds for that reason. It cycles between an oxidised form, NAD+, and a reduced form, NADH, carrying electrons between the reactions of glycolysis, the citric acid cycle and oxidative phosphorylation. Beyond that classical role it is consumed as a substrate by three families of enzymes, which is what has driven the recent research interest. We supply it as a powder at 500mg per vial with an independent certificate of analysis.
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Cytoprotective Peptides
GHK-Cu
GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a sequence first isolated from human plasma in the 1970s and later identified in saliva and urine. The free tripeptide binds copper with high affinity, and it is the copper-bound form that most of the published literature studies. Its plasma concentration in humans declines with age, which is part of why it has been examined in tissue remodelling and gene expression work. We supply it as a lyophilised powder at 50mg per vial, with a batch certificate of analysis reporting HPLC purity and mass spectrometry identity. The copper content is what gives the powder its characteristic blue colour, so a vial that looks white or off-white is not GHK-Cu.
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