CNS Research Peptides
Semax
10mgC₃₇H₅₁N₉O₁₀S
Key Research Findings
- Ashmarin et al. — characterisation of the modified ACTH(4-10) sequence.
- Published rodent brain-tissue BDNF transcription assay data.
- In-vitro neuronal cell-culture studies on ROS generation.
Overview
Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment. Supplied as a lyophilised powder for in-vitro research use only.
Mechanism of Action
Reported in published in-vitro and animal-model studies to modulate BDNF and NGF transcription in hippocampal cell-line assays. Not intended for human or veterinary use.
Research Effects
BDNF Transcription Studies
Extensive ResearchReported in rodent brain-tissue assays as an upregulator of BDNF transcription under controlled conditions.
NGF Pathway Activity
Moderate ResearchPublished cell-culture assays report modulation of nerve growth factor pathway activity.
Neuronal ROS Assays
Moderate ResearchIn-vitro neuronal cell studies report effects on reactive oxygen species generation in oxidative-stress assays.
References
- [1]Dolotov OV, Karpenko EA, Inozemtseva LS, et al.. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006. PMID 16996037 · doi:10.1016/j.brainres.2006.07.108
- [2]Agapova TY, Agniullin YV, Shadrina MI, et al.. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10. Neurosci Lett. 2007. PMID 17353092 · doi:10.1016/j.neulet.2007.02.042
Cited for the molecular pathways described above. Listing a study is not a claim about any outcome in humans.
Laboratory Research Only — All information on this page is provided for scientific research purposes only. This is a certified reference material sample sold and distributed for laboratory research only.
Quick Facts
Research Status Key
Featured in Bundles
Semax is included in the following Zenterex research peptide bundles.
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