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Zenterex Research Chemicals
Zenterex

Research Purposes Only

AOD-9604

Cellular / Energy

AOD-9604

C₇₈H₁₂₃N₂₃O₂₃S₂

Key Research Findings

  • Stimulates lipolysis in vitro at concentrations lower than full-length HGH.
  • Does not raise serum IGF-1 levels, distinguishing its mechanism from full GH.
  • Investigated in clinical trials for obesity treatment — showed safety but modest efficacy as a standalone.
  • Preliminary research suggests possible benefits for cartilage and bone metabolism.

Overview

AOD-9604 is a modified fragment of the C-terminus of human growth hormone (hGH 176–191), developed to isolate the lipolytic properties of HGH without its mitogenic or diabetogenic effects. It is studied for its potential role in fat metabolism and metabolic regulation.

Mechanism of Action

AOD-9604 stimulates lipolysis and inhibits lipogenesis through mechanisms that mirror growth hormone receptor activation specifically in adipose tissue. Unlike full-length HGH, it does not raise IGF-1 levels or promote cell proliferation, making it a selective tool for adipose tissue research.

Research Effects

Fat Metabolism

Extensive Research

Consistent in vitro and animal data showing AOD-9604 stimulates lipolysis and inhibits fat cell differentiation.

Anti-obesity

Moderate Research

Animal models demonstrate body fat reduction; human clinical trials showed safety with modest weight loss results.

Bone & Cartilage

Preliminary Research

Early studies suggest AOD-9604 may support chondrogenesis, with limited evidence from osteoarthritis research models.

Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.

Quick Facts

Molecular FormulaC₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight1816.10 g/mol
CAS Number221231-10-3
SequenceTyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Half-Life~2–3 hours
SolubilityWater (1 mg/mL)
Storage−20 °C, protect from light
More in Cellular / Energy

Research Status Key

Extensive Research
Moderate Research
Preliminary Research

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Growth / Performance

HGH-Frag 176-191

HGH-Fragment 176–191 is a stabilised analogue of the C-terminal fragment of human growth hormone, encompassing amino acids 176 to 191. It was developed to isolate the lipolytic domain of HGH, providing fat metabolism research activity without the growth-promoting, diabetogenic, or mitogenic effects of the full molecule.

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