Cellular / Energy
Cagrilintide
C₁₆₂H₂₆₂N₄₆O₅₂
Key Research Findings
- Combination with semaglutide (CagriSema) demonstrated up to 15.6% body weight reduction in Phase 2 trials.
- Shown to reduce postprandial glucose excursions via glucagon suppression.
- Long-acting half-life (~7 days) enables once-weekly dosing in research protocols.
- Amylin co-agonism with GLP-1 appears to produce additive appetite suppression.
Overview
Cagrilintide is a long-acting amylin analogue developed by Novo Nordisk for research into metabolic and appetite regulation. It is designed to mimic the actions of endogenous amylin — a pancreatic hormone co-secreted with insulin — and is being studied in combination with GLP-1 agonists for metabolic research.
Mechanism of Action
Cagrilintide activates amylin receptors in the hypothalamus and brainstem area postrema, reducing gastric emptying rate, suppressing glucagon secretion, and promoting satiety signalling. Its extended half-life is achieved through fatty acid conjugation, enabling prolonged receptor engagement.
Research Effects
Appetite Regulation
Extensive ResearchActivates amylin receptors in satiety centres; robust clinical evidence for reduced caloric intake and appetite scores.
Weight Management
Extensive ResearchPhase 2 and Phase 3 clinical data show significant body weight reduction, particularly in combination with GLP-1 agonists.
Glycaemic Control
Moderate ResearchReduces postprandial glucose and glucagon levels, with data supporting improved HbA1c in metabolic syndrome research.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
Related Peptides
Cellular / Energy
MOTS-C
MOTS-C is a mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It is unique in that it is generated by the mitochondria themselves and translocated to the nucleus to act as a metabolic regulator, representing a novel category of inter-organelle signalling peptide.
Learn More →
Cellular / Energy
NAD+
Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme found in all living cells, central to cellular energy metabolism and a wide array of signalling pathways. NAD+ levels decline significantly with age, and supplementation is being actively researched in the context of longevity, metabolic health, and neuroprotection.
Learn More →