Anti-Aging
IGF-1 LR3
C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ (approximate)
Key Research Findings
- Half-life extended ~100-fold compared to native IGF-1 due to reduced IGFBP binding.
- Consistently shown to promote skeletal muscle hypertrophy and satellite cell activation in animal models.
- Stimulates neuronal survival and supports axonal regeneration in CNS injury models.
- Activates PI3K/Akt pathway, the primary driver of its anabolic and anti-apoptotic effects.
Overview
IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is a recombinant analogue of endogenous IGF-1, modified with an N-terminal 13-amino acid extension and a glutamic acid-to-arginine substitution at position 3. These changes significantly reduce IGF-binding protein (IGFBP) affinity, extending its half-life from ~12 minutes to approximately 20–30 hours.
Mechanism of Action
IGF-1 LR3 binds the IGF-1 receptor (IGF1R), activating the PI3K/Akt and MAPK/ERK signalling cascades. This promotes protein synthesis, cell proliferation, glucose uptake (via GLUT-4 translocation), and inhibition of apoptosis. Its reduced IGFBP binding means a greater proportion remains in the free, bioactive form.
Research Effects
Muscle Growth
Extensive ResearchRobust animal and in vitro evidence for skeletal muscle hypertrophy via PI3K/Akt/mTOR pathway activation.
Cell Proliferation
Extensive ResearchActs as a potent mitogen for multiple cell types; widely used as a research tool in cell biology.
Metabolic Regulation
Moderate ResearchPromotes glucose uptake and utilisation in muscle and adipose tissue, with research implications for insulin resistance models.
Neuroprotection
Preliminary ResearchEarly studies suggest IGF-1 LR3 supports neuronal survival and may promote recovery in neurodegenerative and injury models.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
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