Anti-Aging
Epitalon
C₁₄H₂₂N₄O₉
Key Research Findings
- Shown to activate telomerase in human somatic cells, extending telomere length in vitro.
- Russian clinical and animal studies spanning 25+ years report anti-aging effects on multiple tissue types.
- Regulates circadian rhythm by modulating pineal gland function and melatonin output.
- Demonstrated increased lifespan in fruit fly and rodent models.
Overview
Epitalon (Epithalon) is a synthetic tetrapeptide derived from the pineal gland peptide Epithalamin, developed by Professor Vladimir Khavinson in Russia. It is studied primarily for its ability to activate telomerase and elongate telomeres, positioning it as a key research compound in the biology of ageing.
Mechanism of Action
Epitalon is thought to stimulate the production of telomerase (TERT), the enzyme responsible for maintaining telomere length on chromosomal ends. Telomere shortening is a hallmark of cellular ageing; by preserving telomere length, Epitalon is researched as a potential modulator of replicative senescence. It also appears to regulate melatonin and cortisol secretion via the pineal gland.
Research Effects
Telomerase Activation
Moderate ResearchIn vitro studies confirm Epitalon-induced TERT expression and measurable telomere elongation in human cell cultures.
Anti-aging
Moderate ResearchExtensive Russian research reports improved biomarkers of ageing across multiple tissue types; methodology of some studies warrants independent replication.
Sleep Regulation
Moderate ResearchModulates pineal melatonin secretion, with research suggesting improvements in circadian rhythm and sleep architecture in aged subjects.
Immune Function
Preliminary ResearchSome studies report enhanced T-cell activity and improved immune surveillance in aged animal models.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
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