Anti-Aging
FOX04-DRI
C₁₀₆H₁₄₁N₂₁O₂₈S₂
Key Research Findings
- First peptide to demonstrate selective senolytic activity via FOXO4–p53 axis disruption.
- Shown to reduce the senescent cell burden in aged mice, restoring fur density and exercise capacity.
- Selectively induces apoptosis in senescent cells while sparing normal quiescent cells.
- Represents a novel mechanistic class of senolytics distinct from ABT-263 (navitoclax).
Overview
FOX04-DRI is a D-retro-inverso peptide designed to disrupt the interaction between the FOXO4 transcription factor and p53 in senescent cells. By blocking this interaction, it is studied as a senolytic agent — a compound that selectively induces apoptosis in senescent 'zombie' cells without affecting healthy cells.
Mechanism of Action
Senescent cells survive by exploiting the FOXO4–p53 axis to suppress apoptosis. FOX04-DRI is a cell-permeable peptide that competitively binds FOXO4, preventing it from sequestering p53 in the nucleus of senescent cells. This frees p53 to trigger apoptosis selectively in senescent cells, while normal cells remain unaffected.
Research Effects
Senolytic Activity
Moderate ResearchPublished mouse studies demonstrate selective elimination of senescent cells via FOXO4–p53 disruption, with measurable improvements in tissue function.
Cellular Senescence Clearance
Moderate ResearchReduces p21 and p16 (senescence markers) in treated tissues, consistent with a reduction in the senescent cell pool.
Healthspan Extension
Preliminary ResearchAged mouse models show improved physical function and organ histology following treatment; human data is not yet available.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
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