Repair / Recovery
KPV
C₁₇H₃₂N₆O₆
Key Research Findings
- Shown to significantly reduce intestinal inflammation in colitis animal models.
- Exhibits direct antimicrobial activity against several clinically relevant pathogens.
- Can penetrate intestinal epithelial cells and act intracellularly, unlike most peptides.
- Oral delivery in nanoparticle form demonstrated efficacy in experimental colitis models.
Overview
KPV is a tripeptide derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). It retains the anti-inflammatory and antimicrobial properties of its parent peptide while exhibiting improved stability and bioavailability in research models.
Mechanism of Action
KPV exerts its anti-inflammatory effects primarily through the melanocortin receptor MC1R and by directly inhibiting NF-κB signalling within intestinal epithelial cells. This mechanism bypasses the systemic side effects associated with conventional anti-inflammatory agents.
Research Effects
Anti-inflammatory
Extensive ResearchRobust evidence for NF-κB inhibition and reduction of pro-inflammatory cytokines (IL-1β, TNF-α) in intestinal models.
Gut Healing
Extensive ResearchDemonstrated mucosal healing and reduction in colitis severity scores in multiple animal models.
Antimicrobial
Moderate ResearchIn vitro studies show activity against S. aureus, E. coli, and Candida species.
Wound Healing
Preliminary ResearchEarly research suggests topical KPV may accelerate skin wound closure via anti-inflammatory mechanisms.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
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