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Zenterex Research Chemicals
Zenterex

Research Purposes Only

TB-500

Repair / Recovery

TB-500

C₂₁₂H₃₅₀N₅₆O₇₈S

Key Research Findings

  • Promotes migration of endothelial cells and keratinocytes, key steps in wound closure and vascularisation.
  • Shown to reduce cardiac fibrosis and improve function in post-infarction animal models.
  • Demonstrates anti-inflammatory properties by downregulating pro-inflammatory cytokines.
  • Synergistic healing effects observed when combined with BPC-157 in musculoskeletal research.

Overview

TB-500 is a synthetic analogue of the naturally occurring peptide Thymosin Beta-4 (Tβ4), a ubiquitous protein involved in actin polymerisation and cell motility. It is studied for its role in tissue repair, wound healing, and anti-inflammatory activity across multiple tissue types.

Mechanism of Action

TB-500 promotes actin polymerisation by sequestering G-actin monomers, which facilitates cell migration and tissue remodelling. It also upregulates cell surface receptors and promotes differentiation of progenitor cells, making it a key mediator of the body's repair response.

Research Effects

Wound Healing

Extensive Research

Robust evidence in animal models for accelerating cutaneous wound closure through enhanced keratinocyte and endothelial cell migration.

Muscle & Tendon Repair

Extensive Research

Research demonstrates improved recovery of muscle and connective tissue injuries, with histological evidence of reduced fibrosis.

Cardioprotection

Moderate Research

Studies in cardiac injury models suggest TB-500 promotes cardiomyocyte survival and reduces infarct size.

Anti-inflammatory

Moderate Research

Downregulates TNF-α and other pro-inflammatory mediators in injury models.

Neuroprotection

Preliminary Research

Early research indicates possible neuroprotective effects in models of spinal cord injury and stroke.

Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.

Quick Facts

Molecular FormulaC₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight4963.44 g/mol
CAS Number77591-33-4
SequenceAc-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln
Half-Life~3–4 hours
SolubilityWater (1 mg/mL)
Storage−20 °C, protect from light
More in Repair / Recovery

Research Status Key

Extensive Research
Moderate Research
Preliminary Research

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Repair / Recovery

BPC-157

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It consists of 15 amino acids and has been studied extensively in animal models for its remarkable tissue-healing properties across multiple organ systems.

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Repair / Recovery

GHK-Cu

GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex) is a naturally occurring copper peptide present in human plasma, saliva, and urine. It plays a central role in wound healing, tissue remodelling, and skin regeneration, with concentration declining significantly with age.

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KPV

KPV is a tripeptide derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). It retains the anti-inflammatory and antimicrobial properties of its parent peptide while exhibiting improved stability and bioavailability in research models.

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