Anti-Aging
MT-2
C₅₀H₆₉N₁₅O₉
Key Research Findings
- Non-selective melanocortin agonist — activates MC1R, MC3R, MC4R, and MC5R subtypes.
- Consistently produces pronounced skin tanning in human and animal subjects via MC1R.
- MC4R activation linked to appetite suppression and energy expenditure in rodent models.
- Cyclic peptide structure confers greater metabolic stability than linear melanocortin analogues.
Overview
MT-2 (Melanotan II) is a cyclic, non-selective melanocortin receptor agonist developed as a shorter, more potent analogue of MT-1. It activates multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R) and has been studied for its diverse effects on pigmentation, energy homeostasis, and physiological regulation.
Mechanism of Action
MT-2 binds to multiple melanocortin receptor subtypes with high affinity. MC1R activation drives melanogenesis and eumelanin production. MC3R and MC4R activation in the hypothalamus modulates appetite, energy expenditure, and autonomic function. The broad receptor profile gives MT-2 a wider range of research effects compared to the selective MT-1.
Research Effects
Melanogenesis
Extensive ResearchStrong evidence for MC1R-driven eumelanin production, consistently producing skin darkening in human and animal studies.
Appetite Regulation
Moderate ResearchMC4R activation in hypothalamic circuits reduces food intake and increases energy expenditure in animal models.
Photoprotection
Moderate ResearchIncreased eumelanin levels provide UV photoprotection, though the degree of protection varies by skin type in research subjects.
Metabolic Effects
Preliminary ResearchEarly research suggests MC3R/MC4R activation by MT-2 influences lipid metabolism and insulin sensitivity.
Research Purposes Only — All information on this page is provided for scientific research purposes only. This product is not intended for human consumption, diagnosis, treatment, or prevention of any disease.
Quick Facts
Research Status Key
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