Cellular Peptides
5-Amino-1MQ
10mgC₁₀H₁₁N₂⁺
Key Research Findings
- Neelakantan et al. — identification and characterisation of 5-Amino-1MQ as a selective small-molecule NNMT inhibitor.
- Published cell-culture studies on NNMT inhibition and associated NAD⁺ / SAM modulation.
- Animal-model studies on white-adipose-tissue metabolism under NNMT-inhibition conditions.
Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Supplied as a lyophilised powder for in-vitro research use only.
Mechanism of Action
Reported in published in-vitro and animal-model studies to competitively inhibit NNMT, the enzyme that methylates nicotinamide. Lowered NNMT activity is reported in cell-culture assays to raise intracellular NAD⁺ and S-adenosylmethionine (SAM) levels. Not intended for human or veterinary use.
Research Effects
NNMT Inhibition Assays
Moderate ResearchReported in cell-culture assays as a competitive inhibitor of nicotinamide N-methyltransferase.
NAD⁺ / SAM Modulation Studies
Preliminary ResearchEarly-stage in-vitro data on intracellular NAD⁺ and S-adenosylmethionine levels under NNMT inhibition.
Adipose-Metabolism Models
Preliminary ResearchAnimal-model studies on white-adipose-tissue metabolism and body-composition endpoints.
Laboratory Research Only — All information on this page is provided for scientific research purposes only. This is a certified reference material sample sold and distributed for laboratory research only.
Quick Facts
Research Status Key
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